Police were called at 22:33 BST on Wednesday to reports of a man injuring people with a knife.
The woman in her 60s was treated at the scene but was pronounced dead shortly after
A 19-year-old man was arrested at 22:39 after a taser was discharged by an officer. The Met said mental health was a "significant factor" in the events.
Two other women and three men received various injuries in the attack, Scotland Yard confirmed later.
The Metropolitan Police has not given any details about the dead woman, other than she was "in her 60s.
A police forensics tent has been erected on Southampton Row, outside the park in the centre of the square, which is close to the British Museum. There is a heavy police presence in the area and the initial cordon around the crime scene has been extended, according to BBC reporter Andy Moore at the scene.
The condition of those injured and the extent of their injuries is not known at present.
Source: BBC
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